https://oldena.lpnu.ua/handle/ntb/51770| Title: | The Expression of Pleiotropic and Pathway-Specific Regulators of Secondary Metabolism in Clorobiocin Producer Streptomyces Roseochromogenes NRRL3504 |
| Authors: | Melnyk, Sofiia Ostash, Bohdan |
| Affiliation: | Ivan Franko National University of Lviv |
| Bibliographic description (Ukraine): | Melnyk S. The Expression of Pleiotropic and Pathway-Specific Regulators of Secondary Metabolism in Clorobiocin Producer Streptomyces Roseochromogenes NRRL3504 / Sofiia Melnyk, Bohdan Ostash // Litteris et Artibus : proceedings, 23–25 November 2018, Lviv. — Lviv : Lviv Politechnic Publishing House, 2018. — P. 218–219. — (7th International academic conference “Chemistry & chemical technology 2018” (CCT-2018)). |
| Bibliographic description (International): | Melnyk S. The Expression of Pleiotropic and Pathway-Specific Regulators of Secondary Metabolism in Clorobiocin Producer Streptomyces Roseochromogenes NRRL3504 / Sofiia Melnyk, Bohdan Ostash // Litteris et Artibus : proceedings, 23–25 November 2018, Lviv. — Lviv : Lviv Politechnic Publishing House, 2018. — P. 218–219. — (7th International academic conference “Chemistry & chemical technology 2018” (CCT-2018)). |
| Is part of: | Litteris et Artibus : proceedings, 2018 |
| Conference/Event: | 8th International youth science forum «Litteris et Artibus» |
| Journal/Collection: | Litteris et Artibus : proceedings |
| Issue Date: | 22-Nov-2018 |
| Publisher: | Видавництво Львівської політехніки Lviv Politechnic Publishing House |
| Place of the edition/event: | Львів Lviv |
| Temporal Coverage: | 23–25 November 2018, Lviv |
| Keywords: | Streptomyces clorobiocin AdpA StrR-like regulators gyrase inhibitors |
| Number of pages: | 2 |
| Page range: | 218-219 |
| Start page: | 218 |
| End page: | 219 |
| Abstract: | Clorobiocin is potent aminocoumarin against resistant pathogens. We describe attempts to improve clorobiocin production via expression of pleiotropic (adpA) and pathway-specific regulatory (cloG, novG) genes in Streptomyces roseochromogenes NRRL3504. Positive influence of adpA on clorobiocin production was revealed. The effects of cloG and novG are under investigation. |
| URI: | https://ena.lpnu.ua/handle/ntb/51770 |
| ISBN: | 978-966-941-294-2 |
| Copyright owner: | © Національний університет “Львівська політехніка”, 2018 |
| References (Ukraine): | [1] S. Alt, L.A. Mitchenall, A. Maxwell and L. Heide. “Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics”. J. Antimicrob. Chemother., vol. 66, pp. 2061-2069, 2011. [2] F. Pojer, S.M. Li, and L. Heide. “Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics”. Microbiology, vol. 148, no. 12, pp. 3901-3911, 2002. [3] L. Heide. “The aminocoumarins: biosynthesis and biology”. Nat. Prod. Rep., vol. 26, no. 10, pp. 1241-1250, 2009. [4] G. Liu, K.F. Chater, G. Chandra, G. Niu and H. Tan. “Molecular regulation of antibiotic biosynthesis in Streptomyces”. Microbiol. Mol. Biol. Rev., vol. 77, no. 1, pp. 112-143, 2013. |
| References (International): | [1] S. Alt, L.A. Mitchenall, A. Maxwell and L. Heide. "Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics". J. Antimicrob. Chemother., vol. 66, pp. 2061-2069, 2011. [2] F. Pojer, S.M. Li, and L. Heide. "Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics". Microbiology, vol. 148, no. 12, pp. 3901-3911, 2002. [3] L. Heide. "The aminocoumarins: biosynthesis and biology". Nat. Prod. Rep., vol. 26, no. 10, pp. 1241-1250, 2009. [4] G. Liu, K.F. Chater, G. Chandra, G. Niu and H. Tan. "Molecular regulation of antibiotic biosynthesis in Streptomyces". Microbiol. Mol. Biol. Rev., vol. 77, no. 1, pp. 112-143, 2013. |
| Content type: | Conference Abstract |
| Appears in Collections: | Litteris et Artibus. – 2018 р. |
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2018_Melnyk_S-The_Expression_of_Pleiotropic_218-219.pdf | 106.19 kB | Adobe PDF | View/Open | |
| 2018_Melnyk_S-The_Expression_of_Pleiotropic_218-219__COVER.png | 497.83 kB | image/png | View/Open |
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