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Please use this identifier to cite or link to this item: https://oldena.lpnu.ua/handle/ntb/46401
Title: Investigation of sorption/desorption processes of medical substances by combined hydrogels
Other Titles: Дослідження процесів сорбції/десорбції лікарських речовин комбінованими гідрогелями
Authors: Майкович, О. В.
Носова, Н. Г.
Борденюк, О. Ю.
Фігурка, Н. В.
Варваренко, С. М.
Maikovych, O. V.
Nosova, N. G.
Bordenyuk, O. Yu.
Fihurka, N. V.
Varvarenko, S. M.
Affiliation: Національний університет “Львівська політехніка”
Lviv Polytechnic National University
Bibliographic description (Ukraine): Investigation of sorption/desorption processes of medical substances by combined hydrogels / O. V. Maikovych, N. G. Nosova, O. Yu. Bordenyuk, N. V. Fihurka, S. M. Varvarenko // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2019. — Том 2. — № 2. — С. 154–158.
Bibliographic description (International): Investigation of sorption/desorption processes of medical substances by combined hydrogels / O. V. Maikovych, N. G. Nosova, O. Yu. Bordenyuk, N. V. Fihurka, S. M. Varvarenko // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2019. — Vol 2. — No 2. — P. 154–158.
Is part of: Chemistry, Technology and Application of Substances, 2 (2), 2019
Issue: 2
Issue Date: 28-Feb-2019
Publisher: Lviv Politechnic Publishing House
Lviv Politechnic Publishing House
Place of the edition/event: Lviv
Lviv
Keywords: гідрогель
колаген
желатин
сорбція
новокаїн
лідокаїн
hydrogel
collagen
gelatin
sorption
novocaine
lidocaine
Number of pages: 5
Page range: 154-158
Start page: 154
End page: 158
Abstract: Наведено результати досліджень щодо сорбції та десорбції комбінованими поліакриламід- желатиновими гідрогелями новокаїну та лідокаїну. Показано, що сорбція/десорбція гідрогелями проходить з різною швидкістю залежно від будови та наявності функціональних груп у структурі речовин, що сорбуються. Під час дослідження десорбції лікарських речовин з полімерної матриці гідрогелю встановлено, що вивільнення новокаїну та лідокаїну відбувається доволі тривалий час, що може забезпечити їх пролонговану доставку. Розроблені гідрогелеві матеріали можуть бути використані в косметології і медицині як трансдермальні системи доставки ліків.
The article represents the results of studies of sorption and desorption of novocaine and lidocaine by combined polyacrylamide gelatinous hydrogels. The rates of sorption by hydrogels are different, depending on the structure and the presence of functional groups in the structure of absorbed substances. The study of the desorption of medicinal substances from the polymeric matrix of hydrogel showed that release of novocaine and lidocaine lasts for a long time, which can ensure their prolonged delivery. Developed hydrogel materials can be used in cosmetology and medicine, as transdermal drug delivery systems.
URI: https://ena.lpnu.ua/handle/ntb/46401
Copyright owner: © Національний університет „Львівська політехніка“, 2019
References (Ukraine): 1. Chai, Q., Jiao, Y, Yu, X.. (2017). Hydrogels for biomedical applications: their characteristics and the mechanisms behind them. Gels, 3(6), 1-15.
2. Hennink, W., Van Nostrum, C. (2012). Novel crosslinking methods to design hydrogels. Advanced Drug Delivery Reviews, 64, 223-236.
3. Seliktar, D. (2012). Designing cell-compatible hydrogels for biomedical applications. Science, 336 (6085), 1124–1128.
4. Hamidi, M., Azadi, A., Rafiei, P. (2008). Hydrogel nanoparticles in drug delivery. Advanced Drug Delivery Reviews, 60, 1638-1649.
5. Vasilev, A. E., Krasnyuk, I. I., Ravikumar, S. (2001). Transdermalnyie terapevticheskie sistemyi dostavki lekarstvennyih veschestv. Himikofarmatsevticheskiy zhurnal, 35(11), 29-42.
6. Samchenko, Yu. M., Pasmurtseva, N. A., Ulberg Z. R. (2007). Diffuziya lekarstvennyih preparatov iz gidrogelevyih nanoreaktorov. Dopovidi NAN Ukrayini, 6, 143-148.
7. Sekine, Y.,Moritani, Y., Fukazawa, T. I., Sasaki, Y., Akiyoshi, K. (2012). A hybrid hydrogel biomaterial by nanogel engineering: bottom-up design with nanogel and liposome building blocks to develop a multidrug delivery system. Advanced healthcare materials, 1(6), 722-728.
8. Wen Zhao, Jin Xing, Cong Yang, Liu Yuying, Fu Jun. (2013). Degradable natural polymer hydrogels for articular cartilage tissue engineering. Journal of Chemical Technology & Biotechnology, 88(3), 327-339.
9. Naahidi, S., Jafari, M., Logan, M., Wang, Y., Yuan, Y., Bae, H.,. Dixon, B, Chen, P. (2017). Biocompatibility of hydrogel-based scaffolds for tissue engineering applications. Biotechnology Advаnces, 35(5), 530-544.
10. J. Tavakoli, Y. Tang Honey. (2017). PVA hybrid wound dressings with controlled release of antibiotics: Structural, physico-mechanical and in vitro biomedical studies. Materials Science and Engineering, 77, 318–325.
11. J. Ramshaw, J. Werkmeister, V. Glatteur. (1995). Collagen based biomaterials. Biotechnol. Rev.,13, 336-382.
12. Amir K. Miri, Hossein Goodarzi, Berivan Cecen, Shabir Hassan, Yu Shrike Zhang. (2018). Permeability mapping of gelatin methacryloyl hydrogels. Acta Biomaterialia,77, 38-47.
13. Nosova, N. G., Samarik, V. Yа., Varvarenko, S. M., Ferens, M. V., Voronovska, A. V., Nagornyak, M. І., Homyak, S. V., Nadashkevich, Z. Yа., Voronov, S. A. (2016). Polyacrylamide porous hydrogels – preparation and properties Voprosyi himii i himicheskoy tehnologiі, 5-6, 78-86.
14. Lavrova, I.S. (1983). Praktikum po kolloidnoy himii. Moscow., Vyisshaya shkola.
15. Samchenko, Yu. M., Pasmurtseva, N. A., Ulberg, Z. R. (2010). Primenenie uf-spektroskopii dlya izucheniya diffuzii lekarstvennyih soedineniy iz gidrogeley meditsinskogo. Jurnal hromatografіchnogo tovaristva,10(1), 4-24.
References (International): 1. Chai, Q., Jiao, Y, Yu, X.. (2017). Hydrogels for biomedical applications: their characteristics and the mechanisms behind them. Gels, 3(6), 1-15.
2. Hennink, W., Van Nostrum, C. (2012). Novel crosslinking methods to design hydrogels. Advanced Drug Delivery Reviews, 64, 223-236.
3. Seliktar, D. (2012). Designing cell-compatible hydrogels for biomedical applications. Science, 336 (6085), 1124–1128.
4. Hamidi, M., Azadi, A., Rafiei, P. (2008). Hydrogel nanoparticles in drug delivery. Advanced Drug Delivery Reviews, 60, 1638-1649.
5. Vasilev, A. E., Krasnyuk, I. I., Ravikumar, S. (2001). Transdermalnyie terapevticheskie sistemyi dostavki lekarstvennyih veschestv. Himikofarmatsevticheskiy zhurnal, 35(11), 29-42.
6. Samchenko, Yu. M., Pasmurtseva, N. A., Ulberg Z. R. (2007). Diffuziya lekarstvennyih preparatov iz gidrogelevyih nanoreaktorov. Dopovidi NAN Ukrayini, 6, 143-148.
7. Sekine, Y.,Moritani, Y., Fukazawa, T. I., Sasaki, Y., Akiyoshi, K. (2012). A hybrid hydrogel biomaterial by nanogel engineering: bottom-up design with nanogel and liposome building blocks to develop a multidrug delivery system. Advanced healthcare materials, 1(6), 722-728.
8. Wen Zhao, Jin Xing, Cong Yang, Liu Yuying, Fu Jun. (2013). Degradable natural polymer hydrogels for articular cartilage tissue engineering. Journal of Chemical Technology & Biotechnology, 88(3), 327-339.
9. Naahidi, S., Jafari, M., Logan, M., Wang, Y., Yuan, Y., Bae, H.,. Dixon, B, Chen, P. (2017). Biocompatibility of hydrogel-based scaffolds for tissue engineering applications. Biotechnology Advances, 35(5), 530-544.
10. J. Tavakoli, Y. Tang Honey. (2017). PVA hybrid wound dressings with controlled release of antibiotics: Structural, physico-mechanical and in vitro biomedical studies. Materials Science and Engineering, 77, 318–325.
11. J. Ramshaw, J. Werkmeister, V. Glatteur. (1995). Collagen based biomaterials. Biotechnol. Rev.,13, 336-382.
12. Amir K. Miri, Hossein Goodarzi, Berivan Cecen, Shabir Hassan, Yu Shrike Zhang. (2018). Permeability mapping of gelatin methacryloyl hydrogels. Acta Biomaterialia,77, 38-47.
13. Nosova, N. G., Samarik, V. Ya., Varvarenko, S. M., Ferens, M. V., Voronovska, A. V., Nagornyak, M. I., Homyak, S. V., Nadashkevich, Z. Ya., Voronov, S. A. (2016). Polyacrylamide porous hydrogels – preparation and properties Voprosyi himii i himicheskoy tehnologii, 5-6, 78-86.
14. Lavrova, I.S. (1983). Praktikum po kolloidnoy himii. Moscow., Vyisshaya shkola.
15. Samchenko, Yu. M., Pasmurtseva, N. A., Ulberg, Z. R. (2010). Primenenie uf-spektroskopii dlya izucheniya diffuzii lekarstvennyih soedineniy iz gidrogeley meditsinskogo. Jurnal hromatografichnogo tovaristva,10(1), 4-24.
Content type: Article
Appears in Collections:Chemistry, Technology and Application of Substances. – 2019. – Vol. 2, No. 2

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