https://oldena.lpnu.ua/handle/ntb/45198| Title: | Optimization studies on biosynthesis of citric acid by one-factor-at-a-time |
| Other Titles: | Оптимізація біосинтезу лимонної кислоти за допомогою монотетичного аналізу чинників |
| Authors: | Kola, Anand Kishore Mekala, Mallaiah Goli, Venkat Reddy |
| Affiliation: | National Institute of Technology, India BV Raju Institute of Technology, India |
| Bibliographic description (Ukraine): | Kola A. K. Optimization studies on biosynthesis of citric acid by one-factor-at-a-time / Anand Kishore Kola, Mallaiah Mekala, Venkat Reddy Goli // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2018. — Vol 12. — No 4. — P. 511–518. |
| Bibliographic description (International): | Kola A. K. Optimization studies on biosynthesis of citric acid by one-factor-at-a-time / Anand Kishore Kola, Mallaiah Mekala, Venkat Reddy Goli // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2018. — Vol 12. — No 4. — P. 511–518. |
| Is part of: | Chemistry & Chemical Technology, 4 (12), 2018 |
| Journal/Collection: | Chemistry & Chemical Technology |
| Issue: | 4 |
| Volume: | 12 |
| Issue Date: | 20-Jan-2018 |
| Publisher: | Lviv Politechnic Publishing House |
| Place of the edition/event: | Lviv |
| Keywords: | лимонна кислота сахароза період інкубації ферментація оптимізація монотетичний аналіз citric acid sucrose incubation time fermentation optimization one-factor-at-a-time method |
| Number of pages: | 8 |
| Page range: | 511-518 |
| Start page: | 511 |
| End page: | 518 |
| Abstract: | Проведено оцінювання чинників процесу біо-
синтезу лимонної кислоти, та проаналізовано їх вплив на резуль-
тат процесу. Встановлено, що такі чинники, як початкова
концентрація сахарози, концентрація метанолу, концентрація
інокуляту, рН вихідного середовища, вірогідність спору,
швидкість обертання мішалки, період інкубації, температура
бродіння, розмір частинок, швидкість потоку кисню та
вологість мають значний вплив на процес. З використанням
експериментального дизайну Плакетта-Бурмана з одинадцяти
чинників визначено ті, які мають найбільший вплив на процес:
початкова концентрація сахарози, рН вихідного середовища,
швидкість обертання мішалки, інкубаційний період,
температура бродіння та витрата кисню. За допомогою
монотетичного аналізу експериментально підтверджений та
критично оцінений вплив чинників на вихід лимонної кислоти. 1In the presented study, the significant operating variables regarding biosynthesis of citric acid process were assessed and their effects on the process yield were analysed. These variables, namely, initial sucrose concentration, methanol concentration, inoculum density, initial medium pH, spore age, stirrer speed, incubation period, fermentation temperature, particle size distribution, oxygen flow rate, and moisture content have significant influence on bioprocess of citric acid production. Plackett-Burman approach was used to determine the most significant variables, which predominantly influence the citric acid production process. Out of the eleven variables, initial sucrose concentration, initial medium pH, stirrer speed, incubation period, fermentation temperature, and oxygen flow rate were found to be significant. The effect of the significant variables on the yield of citric acid has been validated experimentally by one-factor-at-a-time empirical optimization technique. The optimum conditions have been determined. The effect of each variable on the yield of citric acid was analysed critically. |
| URI: | https://ena.lpnu.ua/handle/ntb/45198 |
| Copyright owner: | © Національний університет „Львівська політехніка“, 2018 ©Kola A., Mekala M., Goli V., 2018 |
| URL for reference material: | https://doi.org/10.1016/j.jfoodeng.2004.10.006 https://doi.org/10.1016/j.jbiotec.2004.01.007 https://doi.org/10.1016/S1567-1356(02)00188-5 https://doi.org/10.1007/BF00454376 https://doi.org/10.1007/BF00255358 https://doi.org/10.1016/S0141-0229(97)00041-0 https://doi.org/10.1016/B978-0-444-63662-1.00025-7 https://doi.org/10.1016/j.lwt.2012.05.016 https://doi.org/10.1016/j.biombioe.2013.02.034 https://doi.org/10.1016/j.lwt.2004.04.014 https://doi.org/10.1016/j.sjbs.2012.01.004 https://doi.org/10.1002/(SICI)1097-0290(19990705)64:1<92::AIDBIT10>3.0.CO;2-8 https://doi.org/10.1002/bit.1175 https://doi.org/10.1021/bp000167w https://doi.org/10.2225/vol9-issue4-fulltext-7 https://doi.org/10.1093/biomet/33.4.305 https://doi.org/10.3168/jds.S0022-0302(58)91152-4 https://doi.org/10.1021/ac60147a030 https://doi.org/10.1042/bst0181020 https://doi.org/10.1007/PL00009115 https://doi.org/10.1016/0141-0229(86)90008-6 https://doi.org/10.1007/s002530051651 |
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| Content type: | Article |
| Appears in Collections: | Chemistry & Chemical Technology. – 2018. – Vol. 12, No. 4 |
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