https://oldena.lpnu.ua/handle/ntb/55783| Title: | The Synthesis and In Silico Antihypertensive Activity Prognosis of New Mannich Bases Containing the 1,2,4-Triazole Moiety |
| Other Titles: | Синтез та in silico прогноз антигіпертензивної активності нових основ Манніха, що містять фрагмент 1,2,4-тріазолу |
| Authors: | Perekhoda, Lina Georgiyants, Victoria Yeromina, Hanna Drapak, Iryna Lubenets, Vira Ieromina, Zinaida Sych, Irina Severina, Hanna Demchenko, Anatoly |
| Affiliation: | National University of Pharmacy Danylo Halytsky Lviv National Medical University Lviv National Polytechnic University National Academy of Medical Sciences Nizhyn Mykola Gogol State University |
| Bibliographic description (Ukraine): | The Synthesis and In Silico Antihypertensive Activity Prognosis of New Mannich Bases Containing the 1,2,4-Triazole Moiety / Lina Perekhoda, Victoria Georgiyants, Hanna Yeromina, Iryna Drapak, Vira Lubenets, Zinaida Ieromina, Irina Sych, Hanna Severina, Anatoly Demchenko // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2020. — Vol 14. — No 2. — P. 214–220. |
| Bibliographic description (International): | The Synthesis and In Silico Antihypertensive Activity Prognosis of New Mannich Bases Containing the 1,2,4-Triazole Moiety / Lina Perekhoda, Victoria Georgiyants, Hanna Yeromina, Iryna Drapak, Vira Lubenets, Zinaida Ieromina, Irina Sych, Hanna Severina, Anatoly Demchenko // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2020. — Vol 14. — No 2. — P. 214–220. |
| Is part of: | Chemistry & Chemical Technology, 2 (14), 2020 |
| Issue: | 2 |
| Volume: | 14 |
| Issue Date: | 24-Jan-2020 |
| Publisher: | Видавництво Львівської політехніки Lviv Politechnic Publishing House |
| Place of the edition/event: | Львів Lviv |
| DOI: | doi.org/10.23939/chcht14.02.214 |
| Keywords: | основи Манніха 1 2 4-тріазол синтез антигіпертензивна активність прогноз in silico докінгові дослідження Mannich bases 1 2 4-triazole synthesis antihypertensive activity in silico prognosis docking studies |
| Number of pages: | 7 |
| Page range: | 214-220 |
| Start page: | 214 |
| End page: | 220 |
| Abstract: | У рамках наших постійних досліджень щодо
потенційних антигіпертензивних агентів серед похідних
морфоліну та піперидину було розроблено та синтезовано 10
нових цільових сполук, що містять 1,2,4-тріазольний та морфоліновий або піперидиновий фрагменти. Проведені докінгові
дослідження з метою пошуку біологічно активних речовин
антигіпертензивної дії. Результати in silico досліджень
свідчать, що всі синтезовані сполуки є перспективними інгібіторами ангіотензинперетворюючого ферменту і належать до
4 та 5 класів токсичності згідно класифікації OECР. As a part of our continuous research on potential antihypertensive agents among morpholine and piperidine derivatives, 10 novel target compounds containing 1,2,4-triazole and morpholine or piperidine moieties have been designed and synthesized, and the docking studies have been conducted in order to find biologically active substances with the antihypertensive activity. The in silico studies have shown that all compounds synthesized are promising angiotensin converting enzyme inhibitors and belong to the toxicity class 4 and 5 according to the classification of chemicals by the OECD project. |
| URI: | https://ena.lpnu.ua/handle/ntb/55783 |
| Copyright owner: | © Національний університет “Львівська політехніка”, 2020 © Perekhoda L., Georgiyants V., Yeromina H., Drapak I., Lubenets V., Ieromina Z., Sych I., Severina H., Demchenko A., 2020 |
| URL for reference material: | https://doi.org/10.1111/cbdd.12520 https://doi.org/10.3897/pharmacia.66.e35083 https://doi.org/10.5958/0974-360X.2015.00100.6 https://doi.org/10.1002/med.21634 https://doi.org/10.1016/j.ejmech.2019.05.056 https://doi.org/10.1016/j.bmc.2015.09.034 https://doi.org/10.3390/molecules23071559 https://doi.org/10.1016/j.bmc.2013.10.017 https://doi.org/10.2174/092986712803414213 http://accelrys.com/ http://www.way2drug.com/gusar/acutoxpredict.html https://doi.org/10.5958/0974-360X.2019.00846.1 https://doi.org/10.1074/jbc.M110.167866 https://doi.org/10.1021/ml4004588 http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformati |
| References (Ukraine): | [1] Kang D., Fang Z., Huang B. et al.: Chem. Biol. Drug Design, 2015, 86, 568. https://doi.org/10.1111/cbdd.12520 [2] Drapak І., Zimenkovsky B., Perekhoda L. et al.: Pharmacia, 2019, 66, 33. https://doi.org/10.3897/pharmacia.66.e35083 [3] Ueda Y., Timothy P., Wang I. et al.: Pat. US 8461333 B2, Publ. Jun. 11, 2013. [4] Yradjan M., Yradjan N., Paronykjan R., Stepanjan H.: KhimikoFarmacevt. Zh., 2010, 44, 11. [5] Klen E., Makarova N., Chalyullyn F. et al.: Bashkirsky Khim. Zh., 2008, 15, 112. [6]Jakhmola V., Jawla S., Mishra R.: Acta Sci. Pharm. Sci., 2018, 2, 02. [7] Al-Ghorbani M., Begum B. et al.: J. Chem. Pharm. Res., 2015, 8, 611. https://doi.org/10.5958/0974-360X.2015.00100.6 [8] Kourounakis A., Xanthopoulos D., Tzara A.: Med. Res. Rev., 2020, 40, 709. https://doi.org/10.1002/med.21634 [9] Yan X., Wang Z., Qi P. et al.: Eur. J. Med. Chem., 2019, 177, 425. https://doi.org/10.1016/j.ejmech.2019.05.056 [10] Ladopoulou E., Matralis A., Nikitakis A., Kourounakis A.: Bioorg. Med. Chem., 2015, 23, 7015. https://doi.org/10.1016/j.bmc.2015.09.034 [11] Mytnyk Z., Kolesnyk Ju.: Zaporozhsky Med. Zh., 2010, 12, 79. [12] Bhat M., Al-Omar M., Ghabbour H., Naglah A.: Molecules, 2018, 23, 1559. https://doi.org/10.3390/molecules23071559 [13] Manjusha R., Begum S., Begum A., Bharathi K.: Asian J. Pharm. Clinical Res., 2018, 11, 66. https://doi.org/10.3390/molecules23071559 [14] Kaplaushenko A.: Naukovyi Zh. MOZ Ukrainy, 2013, 3, 152. [15] Sahu N., Sahu J., Kaushik A.: Curr. Res. Pharm. Sci., 2013, 3, 108. [16] Malani A., Makwana A., Makwana H.: Moroccan J. Chem., 2017, 5, 41. [17] Liu J., Liu Q., Yang X. et al.: Bioorgan. Med. Chem., 2013, 21, 7742. https://doi.org/10.1016/j.bmc.2013.10.017 [18] Zhou C.-H., Wang Y.: Current Medicinal Chemistry, 2012, 19, 239. https://doi.org/10.2174/092986712803414213 [19] http://accelrys.com/ [20] http://www.way2drug.com/gusar/acutoxpredict.html [21] Drapak I., Suleiman M., Protopopov M. et al.: Res. J. Pharm. Technol., 2019, 12, 4889. https://doi.org/10.5958/0974-360X.2019.00846.1 [22] Anthony C., Corradi H., Schwager S. et al.: J. Biol. Chem., 2010, 285, 35685. https://doi.org/10.1074/jbc.M110.167866 [23] Kramer G., Mohd A., Schwager S. et al.: ACS Med. Chem. Lett., 2014, 5, 346. https://doi.org/10.1021/ml4004588 [24] http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformati onforpatientsandproviders/ucm102981.htm |
| References (International): | [1] Kang D., Fang Z., Huang B. et al., Chem. Biol. Drug Design, 2015, 86, 568. https://doi.org/10.1111/cbdd.12520 [2] Drapak I., Zimenkovsky B., Perekhoda L. et al., Pharmacia, 2019, 66, 33. https://doi.org/10.3897/pharmacia.66.e35083 [3] Ueda Y., Timothy P., Wang I. et al., Pat. US 8461333 B2, Publ. Jun. 11, 2013. [4] Yradjan M., Yradjan N., Paronykjan R., Stepanjan H., KhimikoFarmacevt. Zh., 2010, 44, 11. [5] Klen E., Makarova N., Chalyullyn F. et al., Bashkirsky Khim. Zh., 2008, 15, 112. [6]Jakhmola V., Jawla S., Mishra R., Acta Sci. Pharm. Sci., 2018, 2, 02. [7] Al-Ghorbani M., Begum B. et al., J. Chem. Pharm. Res., 2015, 8, 611. https://doi.org/10.5958/0974-360X.2015.00100.6 [8] Kourounakis A., Xanthopoulos D., Tzara A., Med. Res. Rev., 2020, 40, 709. https://doi.org/10.1002/med.21634 [9] Yan X., Wang Z., Qi P. et al., Eur. J. Med. Chem., 2019, 177, 425. https://doi.org/10.1016/j.ejmech.2019.05.056 [10] Ladopoulou E., Matralis A., Nikitakis A., Kourounakis A., Bioorg. Med. Chem., 2015, 23, 7015. https://doi.org/10.1016/j.bmc.2015.09.034 [11] Mytnyk Z., Kolesnyk Ju., Zaporozhsky Med. Zh., 2010, 12, 79. [12] Bhat M., Al-Omar M., Ghabbour H., Naglah A., Molecules, 2018, 23, 1559. https://doi.org/10.3390/molecules23071559 [13] Manjusha R., Begum S., Begum A., Bharathi K., Asian J. Pharm. Clinical Res., 2018, 11, 66. https://doi.org/10.3390/molecules23071559 [14] Kaplaushenko A., Naukovyi Zh. MOZ Ukrainy, 2013, 3, 152. [15] Sahu N., Sahu J., Kaushik A., Curr. Res. Pharm. Sci., 2013, 3, 108. [16] Malani A., Makwana A., Makwana H., Moroccan J. Chem., 2017, 5, 41. [17] Liu J., Liu Q., Yang X. et al., Bioorgan. Med. Chem., 2013, 21, 7742. https://doi.org/10.1016/j.bmc.2013.10.017 [18] Zhou C.-H., Wang Y., Current Medicinal Chemistry, 2012, 19, 239. https://doi.org/10.2174/092986712803414213 [19] http://accelrys.com/ [20] http://www.way2drug.com/gusar/acutoxpredict.html [21] Drapak I., Suleiman M., Protopopov M. et al., Res. J. Pharm. Technol., 2019, 12, 4889. https://doi.org/10.5958/0974-360X.2019.00846.1 [22] Anthony C., Corradi H., Schwager S. et al., J. Biol. Chem., 2010, 285, 35685. https://doi.org/10.1074/jbc.M110.167866 [23] Kramer G., Mohd A., Schwager S. et al., ACS Med. Chem. Lett., 2014, 5, 346. https://doi.org/10.1021/ml4004588 [24] http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformati onforpatientsandproviders/ucm102981.htm |
| Content type: | Article |
| Appears in Collections: | Chemistry & Chemical Technology. – 2020. – Vol. 14, No. 2 |
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2020v14n2_Perekhoda_L-The_Synthesis_and_In_214-220.pdf | 572.07 kB | Adobe PDF | View/Open | |
| 2020v14n2_Perekhoda_L-The_Synthesis_and_In_214-220__COVER.png | 534.36 kB | image/png | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.