https://oldena.lpnu.ua/handle/ntb/45203| Title: | New spectrophotometric method of amlodipine besylate determination and its validation |
| Other Titles: | Розроблення нової методики спектрофотометричного визначення амлодипіну безилату та її валідація |
| Authors: | Sulyma, Marta Vasyuk, Svitlana Zhuk, Yulia Kaminskyy, Danylo Chupashko, Olesya Ogurtsov, Volodymyr |
| Affiliation: | Danylo Halytsky Lviv National Medical University Zaporizhia StateMedical University |
| Bibliographic description (Ukraine): | New spectrophotometric method of amlodipine besylate determination and its validation / Marta Sulyma, Svitlana Vasyuk, Yulia Zhuk, Danylo Kaminskyy, Olesya Chupashko, Volodymyr Ogurtsov // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2018. — Vol 12. — No 4. — P. 429–433. |
| Bibliographic description (International): | New spectrophotometric method of amlodipine besylate determination and its validation / Marta Sulyma, Svitlana Vasyuk, Yulia Zhuk, Danylo Kaminskyy, Olesya Chupashko, Volodymyr Ogurtsov // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2018. — Vol 12. — No 4. — P. 429–433. |
| Is part of: | Chemistry & Chemical Technology, 4 (12), 2018 |
| Journal/Collection: | Chemistry & Chemical Technology |
| Issue: | 4 |
| Volume: | 12 |
| Issue Date: | 20-Jan-2018 |
| Publisher: | Lviv Politechnic Publishing House |
| Place of the edition/event: | Lviv |
| Keywords: | амлодипін безилат 2-нафтохінон-4- сульфонат натрію спектрофотометричний аналіз amlodipine besylate sodium 2-naphthoquinone- 4-sulphonate spectrophotometric assay |
| Number of pages: | 5 |
| Page range: | 429-433 |
| Start page: | 429 |
| End page: | 433 |
| Abstract: | Розроблений та валідований простий, точний і
прецизійний спектрофотометричний метод оцінки кількісного
вмісту амлодипіну безилату у таблетках. Метод базується на
взаємодії амлодипіну безилату із натрію 1,2-нафтохінон-4-
сульфонатом у лужному середовищі, за нагрівання реакційної
суміші за 363K протягом 1 хв., з утворенням продукту помаран-
чевого кольору. Спектрофотометричний метод включав вимірю-
вання оптичної густини продукту при 459 нм. При розробленні
методу вивчено та оптимізовано умови реакції. Підпорядкування
закону Бера відбувалось у діапазоні концентрацій 10–20 мкг/мл при RSD 0,825 і 0,559%, а молярний коефіцієнт поглинання складав 2,54·104, діапазон застосування методів становить 67–133% від
номінального вмісту амлодипіну безилату у лікарськихформах. 1Simple, accurate, and precise spectrophotometric method has been developed and validated for the estimation of amlodipine besylate (AML) in tablets. The method is based on the condensation of AML with sodium 1,2-naphthoquinone-4-sulphonate in an alkaline medium when the reaction mixture was heated at 363K for 1 min to form an orange-colored product. The spectrophotometric method involved the measurement of the colored product at 459 nm. The reaction conditions were studied and optimized. Beer’s law was obeyed in the concentration range of 10–20 μg·ml-1 with RSD of 0.825 and 0.559 % and molar absorption of 2.54·104, the range of methods application is 67–133 % of the nominal content of amlodipine besylate in the dosage forms. |
| URI: | https://ena.lpnu.ua/handle/ntb/45203 |
| Copyright owner: | © Національний університет „Львівська політехніка“, 2018 ©Sulyma M., Vasyuk S., Zhuk Yu., Kaminskyy D., Chupashko O., OgurtsovV., 2018 |
| URL for reference material: | https://doi.org/10.1016/j.phrs.2006.04.002 https://doi.org/10.1016/j.arabjc.2013.11.043 https://doi.org/10.1016/j.jpba.2015.12.048 https://doi.org/10.1016/j.arabjc.2013.04.012 https://doi.org/10.1016/j.jpba.2015.01.059 https://doi.org/10.1016/j.ajps.2014.04.002 https://doi.org/10.1016/j.snb.2016.07.165 https://doi.org/10.1016/j.jelechem.2014.11.034 https://doi.org/10.1016/j.snb.2014.08.078 https://doi.org/10.1016/j.jelechem.2017.01.055 https://doi.org/10.1016/j.talanta.2014.07.033 https://doi.org/10.1016/j.bfopcu.2014.01.003 https://doi.org/10.1016/j.arabjc.2009.07.002 https://doi.org/10.1016/S0014-827X(02)00018-6 https://doi.org/10.1016/S0731-7085(02)00610-6 https://doi.org/10.1016/S0014-827X(01)01093-X https://doi.org/10.1016/j.farmac.2004.07.009 http://sphu.org/viddil-dfu/zagalnij-zmist-derzhavno%D1%97-farmakope%D1%97-ukra%D1%97ni-1-vidannya |
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| References (International): | [1] De Portu S., Menditto E., Scalone L. et al., Pharmacol. Res.,2006, 54, 158. https://doi.org/10.1016/j.phrs.2006.04.002 [2] Reynolds E., Martindale W., The Extra Pharmacopoeia, 31st ed., The Royal Pharmaceutical Society, London 1996. [3] Kavathia A., MisraM., Arab. J. Chem., 2017, 10, 3021.https://doi.org/10.1016/j.arabjc.2013.11.043 [4] Kannappan V., Mannemala S., J. Pharmaceut. Biomed., 2016,120, 221. https://doi.org/10.1016/j.jpba.2015.12.048 [5] Shaalan R., Belal T., El Yazbi F., Elonsy S., Arab. J. Chem.,2017, 10, 1381. https://doi.org/10.1016/j.arabjc.2013.04.012 [6] Vojta J., Jedlička A., Coufal P., Janečková L., J. Pharmaceut. Biomed., 2015, 109, 36. https://doi.org/10.1016/j.jpba.2015.01.059 [7]Moon H., Yousaf A., Cho K., et al., Asian J. Pharm. Sci., 2014,9, 123. https://doi.org/10.1016/j.ajps.2014.04.002 [8]Moussa B., El-Zaher A., MahrouseM., AhmedM., Anal. Chem. Insights, 2013, 8, 107. ttps://doi.org/10.4137/ACI.S12921 [9] KhairyM., Khorshed A., Rashwan F. et al., Sensor. Actuator. B,2017, 239, 768. https://doi.org/10.1016/j.snb.2016.07.165 [10]MansanoG., Eisele A., Dall’Antonia L. et al., J. Electroanal. Chem., 2015, 738, 188. https://doi.org/10.1016/j.jelechem.2014.11.034 [11] Valezi C., Duarte E., Mansano G. et al., Sensor. Actuator. B,2014, 205, 234. https://doi.org/10.1016/j.snb.2014.08.078 [12] Jadon N., Jain R., Pandey A., J. Electroanal. Chem., 2017, 788,7. https://doi.org/10.1016/j.jelechem.2017.01.055 [13] Norouzi P., Gupta V., Larijani B., Talanta, 2015, 131, 577.https://doi.org/10.1016/j.talanta.2014.07.033 [14] Alizadeh N., Hemati F., B. Facult. Pharmacy, Cairo University,2014, 52, 109. https://doi.org/10.1016/j.bfopcu.2014.01.003 [15] Shama S., Amin A., El SayedM., Omara H., Arab. J. Chem.,2009, 2, 59. https://doi.org/10.1016/j.arabjc.2009.07.002 [16] Basavaiah K., Chandrashekar U., Prameela H., Il Farmaco,2003, 58, 141. https://doi.org/10.1016/S0014-827X(02)00018-6 [17] Rahman N., HodaM., J. Pharmaceut. Biomed., 2003, 31, 381.https://doi.org/10.1016/S0731-7085(02)00610-6 [18] Rahman N., Azmi S., Il Farmaco, 2001, 56, 731.https://doi.org/10.1016/S0014-827X(01)01093-X [19] Rahman N., SinghM., HodaM., Il Farmaco, 2004, 59, 913.https://doi.org/10.1016/j.farmac.2004.07.009 [20] Iskender G., Sagirh A., Acta Pharm. Turcica, 2000, 42, 1. [21] Cetin G., Sungur S., Sci. Pharm., 1995, 63, 93. [22] Rose J., Advanced Physico-Chemical Experiments, Pitman, London 1964. [23] BulatovM., Kalinin I., Prakticheskoe Rukovodstvo po Photocolorimetricheskym Metodam Analiza, 5th edn. Khimiya, Leningrad 1986. [24] Derzhavna Pharmacopeia Ukrainy, 1st edn.http://sphu.org/viddil-dfu/zagalnij-zmist-derzhavno%D1%97-farmakope%D1%97-ukra%D1%97ni-1-vidannya |
| Content type: | Article |
| Appears in Collections: | Chemistry & Chemical Technology. – 2018. – Vol. 12, No. 4 |
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