| DC Field | Value | Language |
|---|
| dc.contributor.author | Yuanita, Emmy | |
| dc.contributor.author | Pranowo, Harno Dwi | |
| dc.contributor.author | Siswanta, Dwi | |
| dc.contributor.author | Swasono, Respati Tri | |
| dc.contributor.author | Mustofa | |
| dc.contributor.author | Zulkarnain, Abdul Karim | |
| dc.contributor.author | Syahri, Jufrizal | |
| dc.contributor.author | Jumina | |
| dc.date.accessioned | 2019-06-20T11:19:49Z | - |
| dc.date.available | 2019-06-20T11:19:49Z | - |
| dc.date.created | 2018-01-20 | |
| dc.date.issued | 2018-01-20 | |
| dc.identifier.citation | One-pot synthesis, antioxidant activity and toxicity evaluation of some hydroxyxanthones / Emmy Yuanita, Harno Dwi Pranowo, Dwi Siswanta, Respati Tri Swasono, Mustofa, Abdul Karim Zulkarnain, Jufrizal Syahri, Jumina // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2018. — Vol 12. — No 3. — P. 290–295. | |
| dc.identifier.uri | https://ena.lpnu.ua/handle/ntb/45184 | - |
| dc.description.abstract | За допомогою одностадійої реакції цикло-
дегідрування похідних гідроксибензенової кислоти (саліцилова
або резорцилова кислота) з флороглюціном або пірогалолом у
присутності реагенту Ітона (P2O5/MeSO3H) одержано нові
сполуки гідроксиксантону. Для визначення інгібуючої
концентрації (IC50) синтезованих сполук їх антиокиснювальну
активність перевірено за допомогою 2,2-дифеніл-1-пікрилгід-
разилу. Цитотоксичність отриманих сполук оцінено MТT-
тестом на лінії клітин Vero. Встановлено, що положення та
кількість гідроксильних груп можуть суттєво вплинути на
потенційну антиокиснювальну активність приготовлених
сполук. Показано, що синтезовані сполуки гідроксиксантону
можна класифікувати як сильні антиоксиданти та їх можна
використовувати в промисловості. | |
| dc.description.abstract | Some new hydroxyxanthone compounds were
prepared through one pot cyclodehydration reaction of
hydroxybenzoic acid derivatives (salicylic acid or
resorcylic acid) with phloroglucinol or pyrogallol in the
presence of Eaton’s reagent (P2O5/MeSO3H). The synthesized
compounds were screened for their antioxidant
activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH)
methods to determine their inhibitory concentration (IC50).
Cytotoxicity of the prepared compounds was also
evaluated by MMT assay on Vero cell line. It was
observed that the position and the number of hydroxyl
groups could significantly affect the potent antioxidant
activity of the prepared compounds. Cytotoxicity
evaluation of new compounds indicated that the
synthesized series of hydroxyl xanthone were categorized
as very strong antioxidants and showed potential
development as a commercial antioxidant compound. | |
| dc.format.extent | 290-295 | |
| dc.language.iso | en | |
| dc.publisher | Lviv Politechnic Publishing House | |
| dc.relation.ispartof | Chemistry & Chemical Technology, 3 (12), 2018 | |
| dc.relation.uri | https://doi.org/10.3390/molecules15106905 | |
| dc.relation.uri | https://doi.org/10.1016/j.ejmech.2011.01.043 | |
| dc.relation.uri | https://doi.org/10.1080/87559129.2015.1022832 | |
| dc.relation.uri | https://doi.org/10.1016/j.supflu.2009.03.004 | |
| dc.relation.uri | https://doi.org/10.1007/BF02901825 | |
| dc.relation.uri | https://doi.org/10.1016/j.bmcl.2005.08.099 | |
| dc.relation.uri | https://doi.org/10.1021/jf405570u | |
| dc.relation.uri | https://doi.org/10.1016/j.bmc.2010.07.044 | |
| dc.relation.uri | https://doi.org/10.1021/jo00984a016 | |
| dc.relation.uri | https://doi.org/10.1039/p19730001329 | |
| dc.relation.uri | https://doi.org/10.1021/jo00324a012 | |
| dc.relation.uri | https://doi.org/10.1039/JR9580004227 | |
| dc.relation.uri | https://doi.org/10.1039/jr9580004234 | |
| dc.relation.uri | https://doi.org/10.1039/jr9610002312 | |
| dc.relation.uri | https://doi.org/10.1248/cpb.54.1653 | |
| dc.relation.uri | https://doi.org/10.1016/j.tet.2013.12.055 | |
| dc.relation.uri | https://doi.org/10.1016/j.bmc.2012.11.014 | |
| dc.relation.uri | https://doi.org/10.1016/j.bmc.2007.06.037 | |
| dc.relation.uri | https://doi.org/10.1016/j.bmc.2007.02.030 | |
| dc.relation.uri | https://doi.org/10.1016/j.tetlet.2014.09.119 | |
| dc.relation.uri | https://doi.org/10.1016/S0223-5234(01)01332-0 | |
| dc.relation.uri | https://doi.org/10.1016/j.ejmech.2014.07.076 | |
| dc.relation.uri | https://doi.org/10.13005/ojc/330104 | |
| dc.relation.uri | https://doi.org/10.1016/S0887-2333(03)00017-1 | |
| dc.relation.uri | https://doi.org/10.1016/j.foodres.2012.12.035 | |
| dc.relation.uri | https://doi.org/10.1186/1743-422X-9-98 | |
| dc.relation.uri | https://doi.org/10.1039/jr9550003982 | |
| dc.relation.uri | https://doi.org/10.2174/092986705774370736 | |
| dc.relation.uri | https://doi.org/10.1016/j.biortech.2004.02.024 | |
| dc.relation.uri | https://doi.org/10.1016/j.foodchem.2006.09.011 | |
| dc.relation.uri | https://doi.org/10.1016/j.foodres.2007.10.001 | |
| dc.relation.uri | https://doi.org/10.1155/2009/612805 | |
| dc.relation.uri | https://doi.org/10.1111/j.1365-2621.2003.tb07029.x | |
| dc.relation.uri | https://doi.org/10.1016/0022-1759(83)90303-4 | |
| dc.relation.uri | https://doi.org/10.1002/cyto.10080 | |
| dc.subject | антиоксидант | |
| dc.subject | гідроксиксантони | |
| dc.subject | 2 | |
| dc.subject | 2- дифеніл-1-пікрилгідразил | |
| dc.subject | реагент Ітона | |
| dc.subject | antioxidant | |
| dc.subject | hydroxyxanthones | |
| dc.subject | 2 | |
| dc.subject | 2-diphenyl- 1-picrylhydrazyl assay | |
| dc.subject | Eaton’s reagent | |
| dc.title | One-pot synthesis, antioxidant activity and toxicity evaluation of some hydroxyxanthones | |
| dc.title.alternative | Одностадійний синтез і оцінка антиокиснювальної активності та токсичності деяких гідроксиксантонів | |
| dc.type | Article | |
| dc.rights.holder | © Національний університет „Львівська політехніка“, 2018 | |
| dc.rights.holder | ©Yuanita E., Pranowo H., Siswanta D., Swasono R., Mustofa, ZulkarnainA., Syahri J., Jumina, 2018 | |
| dc.contributor.affiliation | Universitas Mataram, Indonesia | |
| dc.contributor.affiliation | Universitas Gadjah, Mada, Indonesia | |
| dc.contributor.affiliation | Universitas Muhammadiyah Riau, Indonesia | |
| dc.format.pages | 6 | |
| dc.identifier.citationen | One-pot synthesis, antioxidant activity and toxicity evaluation of some hydroxyxanthones / Emmy Yuanita, Harno Dwi Pranowo, Dwi Siswanta, Respati Tri Swasono, Mustofa, Abdul Karim Zulkarnain, Jufrizal Syahri, Jumina // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2018. — Vol 12. — No 3. — P. 290–295. | |
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| dc.relation.referencesen | [2] Cheng J., Huang A., Hour T., Yang S., Eur. J. Med. Chem.,2011, 46, 1222. https://doi.org/10.1016/j.ejmech.2011.01.043 | |
| dc.relation.referencesen | [3] Stefoska-Needham A., Beck E., Johnson S., Tapsell L., Food Rev. Inter., 2015, 31, 401.https://doi.org/10.1080/87559129.2015.1022832 | |
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| dc.relation.referencesen | [5] Zarena A., Sankar K., J. Supercrit. Fluid., 2009, 4, 330.https://doi.org/10.1016/j.supflu.2009.03.004 | |
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| dc.relation.referencesen | [8] PlazaM., Pozzo T., Liu J. et al., J. Agric. Food. Chem., 2014,62, 3321. https://doi.org/10.1021/jf405570u | |
| dc.relation.referencesen | [9] Santos C., FreitasM., Ribeiro D. et al., Bioorg. Med. Chem.2010,18, 6776. https://doi.org/10.1016/j.bmc.2010.07.044 | |
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| dc.relation.referencesen | [13] Quillinan A., Scheinmann F., J. Chem. Soc. Perk. T. 1, 1973, 0,1329. https://doi.org/10.1039/p19730001329 | |
| dc.relation.referencesen | [14] Sandifer R., Bhattacharya A., Harris T., J. Org. Chem., 1981;46, 2260. https://doi.org/10.1021/jo00324a012 | |
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| dc.relation.referencesen | [16] Goldberg A., Wragg A., J. Chem. Soc., 1958, 0, 4234.https://doi.org/10.1039/jr9580004234 | |
| dc.relation.referencesen | [17] Hassall C., Lewis J., J. Chem. Soc., 1961, 0, 2312.https://doi.org/10.1039/jr9610002312 | |
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| dc.relation.referencesen | [29] Borges G., Gonzaga L., Jardini F. et al., Food Res. Int., 2013,51, 363. https://doi.org/10.1016/j.foodres.2012.12.035 | |
| dc.relation.referencesen | [30]Molyneux P., Songklanakarin J. Sci. Technol., 2004, 26, 211. | |
| dc.relation.referencesen | [31] Bag P., Chattopadhyay D., Mukherjee H. et al., J. Virol., 2012,9, 98. https://doi.org/10.1186/1743-422X-9-98 | |
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| dc.relation.referencesen | [33] SousaM., PintoM., Curr. Med. Chem., 2005, 12, 2447.https://doi.org/10.2174/092986705774370736 | |
| dc.relation.referencesen | [34] Setha B., Gaspersz F., Fidors A. et al., Int. J. Sci. Tech. Res.,2013, 26, 221. | |
| dc.relation.referencesen | [35] Dizhbite T., Telysheva G., Jurkjane V., Viesturs U. : Biores. Technol., 2004, 95, 309.https://doi.org/10.1016/j.biortech.2004.02.024 | |
| dc.relation.referencesen | [36] Susanti D., Sirat H., Ahmad F. et al., Food Chem., 2007, 103,710. https://doi.org/10.1016/j.foodchem.2006.09.011 | |
| dc.relation.referencesen | [37] Ali S., Kasoju N., Luthra A. et al., Food. Res. Int., 2008, 41, 1.https://doi.org/10.1016/j.foodres.2007.10.001 | |
| dc.relation.referencesen | [38] Prasad K., Hao J., Yi C. et al., J. Biomed. Biotech., 2009, 2009,1. https://doi.org/10.1155/2009/612805 | |
| dc.relation.referencesen | [39] JunM., Fu H-Y., Hong J. et al., J. Food Sci., 2003, 68, 2117.https://doi.org/10.1111/j.1365-2621.2003.tb07029.x | |
| dc.relation.referencesen | [40] Bondet V., Williams W., Berset C., Lebensmittel- WissenschaftUnTechnologie, 1997, 30, 609. | |
| dc.relation.referencesen | [41]Mosmann T., J. Immunol. Method., 1983, 65, 55.https://doi.org/10.1016/0022-1759(83)90303-4 | |
| dc.relation.referencesen | [42] Bernas T., Dobrucki J., Cytometry, 2002, 47, 236.https://doi.org/10.1002/cyto.10080 | |
| dc.citation.journalTitle | Chemistry & Chemical Technology | |
| dc.citation.volume | 12 | |
| dc.citation.issue | 3 | |
| dc.citation.spage | 290 | |
| dc.citation.epage | 295 | |
| dc.coverage.placename | Lviv | |
| Appears in Collections: | Chemistry & Chemical Technology. – 2018. – Vol. 12, No. 3
|
