| DC Field | Value | Language |
|---|
| dc.contributor.author | Монька, Н. Я. | |
| dc.contributor.author | Василюк, С. В. | |
| dc.contributor.author | Хоміцька, Г. М. | |
| dc.contributor.author | Шиян, Г. Б. | |
| dc.contributor.author | Лубенець, В. І. | |
| dc.contributor.author | Monka, N. Ya. | |
| dc.contributor.author | Vasylyuk, S. V. | |
| dc.contributor.author | Khomitska, G. M. | |
| dc.contributor.author | Shiyan, G. B. | |
| dc.contributor.author | Lubenets, V. I. | |
| dc.date.accessioned | 2019-05-21T12:54:07Z | - |
| dc.date.available | 2019-05-21T12:54:07Z | - |
| dc.date.created | 2018-02-26 | |
| dc.date.issued | 2018-02-26 | |
| dc.identifier.citation | Модифікація бензилфталіміду тіосульфонатним фрагментом та віртуальний скринінг біологічної активності одержаних тіосульфоестерів / Н. Я. Монька, С. В. Василюк, Г. М. Хоміцька, Г. Б. Шиян, В. І. Лубенець // Chemistry, Technology and Application of Substance. — Lviv : Lviv Politechnic Publishing House, 2018. — Vol 1. — No 1. — P. 59–65. | |
| dc.identifier.uri | https://ena.lpnu.ua/handle/ntb/45009 | - |
| dc.description.abstract | Розроблено альтернативний спосіб синтезу перспективних S-естерів 4-фталімідо-
метилбензентіосульфокислоти. Здійснено прогнозований скринінг біологічної актив-
ності синтезованих тіосульфоестерів з використанням програми PASS. На основі даних
віртуального скринінгу виявлено перспективні напрями експериментальних біоло-
гічних досліджень естерів 4-фталімідометилбензентіосульфокислоти. З використанням
безкоштовно доступного онлайнового сервісу GUSAR проведено in silico визначення
гострої токсичності синтезованих тіосульфоестерів для щурів за чотирма типами
введення субстанції. | |
| dc.description.abstract | The alternative way of synthesis of promising S-esters of 4-phthalimidomethylbenzenethiosulfonic
acid has been developed. The predicted screening of the biological activity of
synthesized thiosulfoesters has been performed with using of program PASS. The perspective
directions of experimental biological researches of esters of 4-phthalimidomethylbenzenethiosulfonic
acid have been identified on the basis of virtual screening data. Using the freely
available on-line service GUSAR, in silico determination of acute rat toxicity of synthesized
thiosulfoesters have been carried out with four type of administration of substancet. | |
| dc.format.extent | 59-65 | |
| dc.language.iso | uk | |
| dc.publisher | Lviv Politechnic Publishing House | |
| dc.relation.ispartof | Chemistry, Technology and Application of Substance, 1 (1), 2018 | |
| dc.subject | солі тіосульфокислот | |
| dc.subject | тіосульфоестери | |
| dc.subject | N-бензилфталімід | |
| dc.subject | естери 4-фталімідометилбензентіосульфокислоти | |
| dc.subject | віртуальний фармакологічний скринінг | |
| dc.subject | thiosulfoacid salts | |
| dc.subject | thiosulfoesters | |
| dc.subject | N-benzylphthalimide | |
| dc.subject | 4-phthalimidomethylbenzenthiosulfoacid esters | |
| dc.subject | virtual pharmacological screening | |
| dc.title | Модифікація бензилфталіміду тіосульфонатним фрагментом та віртуальний скринінг біологічної активності одержаних тіосульфоестерів | |
| dc.title.alternative | Modification of benzylphthalimide by thiosulfonate fragment and virtual screening of biological activity of obtained tiosolphoesters | |
| dc.type | Article | |
| dc.rights.holder | © Національний університет „Львівська політехніка“, 2018 | |
| dc.rights.holder | © Монька Н. Я., Василюк С. В., Хоміцька Г. М., Шиян Г. Б.,Лубенець В. І., 2018 | |
| dc.contributor.affiliation | Національний університет “Львівська політехніка” | |
| dc.format.pages | 7 | |
| dc.identifier.citationen | Modification of benzylphthalimide by thiosulfonate fragment and virtual screening of biological activity of obtained tiosolphoesters / N. Ya. Monka, S. V. Vasylyuk, G. M. Khomitska, G. B. Shiyan, V. I. Lubenets // Chemistry, Technology and Application of Substance. — Lviv : Lviv Politechnic Publishing House, 2018. — Vol 1. — No 1. — P. 59–65. | |
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| dc.relation.references | 9. Phoebe F. Lamie. Design, Synthesis and Evaluation of Novel Phthalimide Derivatives as in Vitro Anti-Microbial, Anti-Oxidant and Anti-Inflammatory Agents / Phoebe F. Lamie, John N. Philoppes, Ahmed O. El-Gendy, Lucie Rarova, Jiri Gruz // Molecules. – 2015. – Vоl. 20. – P. 16620–16642. | |
| dc.relation.references | 10. Shiradkar M. R. Synthesis and anti-convulsant activity of clubbed thiazolidinone-barbituric acid and thiazolidinone–triazole derivatives / Shiradkar M. R., Ghodake M., Bothara K. G., Bhandari S. V., Nikalje A., Akula K. C., Desai N. C., Burange P. J. // ARKIVOC. – 2007. – Vоl. XIV. – P. 58–74. | |
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| dc.relation.references | 12. Mavrova A. T., Wesselinova D., Tsenov Y. A., Denkova P. Synthesis, cytotoxicity and effects of some 1,2,4-triazole and 1,3,4-thiadiazole derivatives on immunocompetent cells / Mavrova A. T., Wesselinova D., Tsenov Y.A., Denkova P. // Eur. J. Med. Chem. – 2009. – Vоl. 44. –P. 63–69. | |
| dc.relation.references | 13. Pertino M. W. Synthesis and anti-proliferative activity of some novel triazole derivatives from dehydroabietic acid / Pertino M. W., Verdugo V., Theoduloz C., Hirschmann G. S.// Molecules. –2014. – Vоl. 19. – P. 2523–2535. | |
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| dc.relation.references | 17. Монька Н. Я Синтез S-естерів 4-фталімідометилбензентіосульфокислоти / Монь- ка Н. Я., Василюк С. В., Наконечна А. В., Баранович Д. Б., Шиян Г. Б., Лубенець В. І. // Хімія, технологія речовин та їх застосування: Вісник Національного університету “Львівська політех- ніка”. – 2015. – № 812. – С. 274–280. | |
| dc.relation.references | 18. Filimonov D. A. Prediction of biological activity spectrum for organic compounds / Filimonov D. A., Poroikov V. V. // Rus. Chem. J. – 2006. – Vоl. 50. – P. 66–75. | |
| dc.relation.references | 19. Lagunin A. QSAR modelling of rat acute toxicity on the basis of PASS prediction / Lagunin A., Zakharov A., Filimonov D., Poroikov V. // Molecular Informatics. – 2011. – Vоl. 30(2–3). – P. 241–250. | |
| dc.relation.referencesen | 1. Entesar O. Al. Tamimi. Synthesis and characterization of some new N-substituted phthalimide, Entesar O. Al. Tamimi, Muna I. Khalaf, Raghad A. Abd Al-Jabar, The Pharmaceutical and Chemical Journal, 2016, Vol. 3(4), P. 202–207. | |
| dc.relation.referencesen | 2. Kamal, A. Naphthalimide derivatives with therapeutic characteristics: A patent review, Kamal A., Bolla N. R., Srikanth P. S., Srivastava A. K., Expert Opin. Ther. Pat, 2013, Vol. 23, P. 299–317. | |
| dc.relation.referencesen | 3. Amin K. M. Synthesis, characterization and anti-microbial activity of some novel isoindole-1,3-dione derivatives, Amin, K. M., El-masry A. H., Mohamed N. A., Awad G. E. A., Habib B. S., Der Pharm. Chem, 2013, Vol. 5, P. 97–108. | |
| dc.relation.referencesen | 4. El-Gaby M. S. A. A novel Synthesis of dibenzo[c,f]chromenes, dibenzo[c,h]chromenes and benzo[7,8]chromeno[3,4-f]isoindoles as anti-microbial agents, El-Gaby M. S. A., Zahran M. A., Ismail M. M. F., Ammar Y. A. A., Il Farmaco, 2000, Vol. 55, P. 227–232. | |
| dc.relation.referencesen | 5. Siddiqui N. J. Synthesis and anti-microbial activities of some new pyrazoles, oxadiazoles and isoxazole bearing benzofuran moiety, Siddiqui N. J., IdreesM., Khati N. T., Dho M. G., S. Afr. J. Chem, 2013, Vol. 66, P. 248–253. | |
| dc.relation.referencesen | 6. Rajasekaran S. Design, synthesis, antibacterial and in vitro anti-oxidant activity of substituted 2H-benzopyran-2-one derivatives, Rajasekaran S., Rao G.K., Pai S., Ranjan A., Int. J. ChemTech Res, 2011, Vol. 3, P. 555–559. | |
| dc.relation.referencesen | 7. Anthony P. Regioselectivesynthesisof 1,4-disubstituted 1,2,3-bistriazoles and their anti-fungal and antioxidant evaluation, Anthony P., Bashir N., Parveen R., Asian J. Biomed. Pharm. Sci, 2014, Vol. 4, –P. 9–13. | |
| dc.relation.referencesen | 8. Pophale R. A. Synthesis and evaluation of novel phthalimide derivatives as analgesic and antiinflammatory agents, Pophale R. A., Deodhar M. N., Der Pharm. Chem, 2010, Vol. 2. –P. 185–193. | |
| dc.relation.referencesen | 9. Phoebe F. Lamie. Design, Synthesis and Evaluation of Novel Phthalimide Derivatives as in Vitro Anti-Microbial, Anti-Oxidant and Anti-Inflammatory Agents, Phoebe F. Lamie, John N. Philoppes, Ahmed O. El-Gendy, Lucie Rarova, Jiri Gruz, Molecules, 2015, Vol. 20, P. 16620–16642. | |
| dc.relation.referencesen | 10. Shiradkar M. R. Synthesis and anti-convulsant activity of clubbed thiazolidinone-barbituric acid and thiazolidinone–triazole derivatives, Shiradkar M. R., Ghodake M., Bothara K. G., Bhandari S. V., Nikalje A., Akula K. C., Desai N. C., Burange P. J., ARKIVOC, 2007, Vol. XIV, P. 58–74. | |
| dc.relation.referencesen | 11. Moffet R. S. Central Nervous System Depressants. VII.1 pyridylcoumarins. J. Med. Chem. –1964, Vol. 7, P. 446–449. | |
| dc.relation.referencesen | 12. Mavrova A. T., Wesselinova D., Tsenov Y. A., Denkova P. Synthesis, cytotoxicity and effects of some 1,2,4-triazole and 1,3,4-thiadiazole derivatives on immunocompetent cells, Mavrova A. T., Wesselinova D., Tsenov Y.A., Denkova P., Eur. J. Med. Chem, 2009, Vol. 44. –P. 63–69. | |
| dc.relation.referencesen | 13. Pertino M. W. Synthesis and anti-proliferative activity of some novel triazole derivatives from dehydroabietic acid, Pertino M. W., Verdugo V., Theoduloz C., Hirschmann G. S.// Molecules. –2014, Vol. 19, P. 2523–2535. | |
| dc.relation.referencesen | 14. Sharma V. Exploring potential of 1,2,4-triazole: A brief review., Sharma V., Shrivastava B., Bhatia R., Bachwani M., Bachwani M., Khandelwal R., Ameta J., Pharmacol. Online, 2011, Vol. 1, P. 1192–1222. | |
| dc.relation.referencesen | 15. Boldyrev B. H. Protivomikrobnaia i fiziolohicheskaia aktivnost efirov tiosulfokislot i vozmozhnye puti ikh prakticheskoho ispolzovaniia v razlichnykh oblastiakh narodnoho khoziaistva, B. H. Boldyrev, T. K. Bilozor, R. I. Vliazlo [and other], Biopovrezhdeniia v promyshlennosti, Horkii: HHU, 1983, P. 44–52. | |
| dc.relation.referencesen | 16. Trost B. M. Alpha- Sulphenylated Carbonyl Compounds in Organic Synthesis, Trost B. M., Chem. Rev, 1978, No. 78. –R. 363. | |
| dc.relation.referencesen | 17. Monka N. Ya Syntez S-esteriv 4-ftalimidometylbenzentiosulfokysloty, Mon- ka N. Ya., Vasyliuk S. V., Nakonechna A. V., Baranovych D. B., Shyian H. B., Lubenets V. I., Khimiia, tekhnolohiia rechovyn ta yikh zastosuvannia: Visnyk Natsionalnoho universytetu "Lvivska politekh- nika", 2015, No 812, P. 274–280. | |
| dc.relation.referencesen | 18. Filimonov D. A. Prediction of biological activity spectrum for organic compounds, Filimonov D. A., Poroikov V. V., Rus. Chem. J, 2006, Vol. 50, P. 66–75. | |
| dc.relation.referencesen | 19. Lagunin A. QSAR modelling of rat acute toxicity on the basis of PASS prediction, Lagunin A., Zakharov A., Filimonov D., Poroikov V., Molecular Informatics, 2011, Vol. 30(2–3), P. 241–250. | |
| dc.citation.journalTitle | Chemistry, Technology and Application of Substance | |
| dc.citation.volume | 1 | |
| dc.citation.issue | 1 | |
| dc.citation.spage | 59 | |
| dc.citation.epage | 65 | |
| dc.coverage.placename | Lviv | |
| Appears in Collections: | Chemistry, Technology and Application of Substances. – 2018. – Vol. 1, No. 1
|
