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Please use this identifier to cite or link to this item: https://oldena.lpnu.ua/handle/ntb/42125
Title: Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma
Other Titles: Оцінка методу квантифікації платини у цисплатині індуційно-зв’язаною плазмою
Authors: Torres, Maykel Gonzalez
Torres, Carolina Munoz
Torres, Ataulfo Martinez
Munoz, Susana Vargas
Talavera, Rogelio Rodriguez
Ruiz-Baltazar, Alvaro de Jesus
Brostow, Witold
Affiliation: Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México
Centro de Geociencias, Universidad Nacional Autónoma de México, Campus Juriquilla
Laboratorio de Neurobiologia Molecular y Celular, Instituto de Neurobiología (INB), Universidad Nacional Autónoma de México
Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México
Department of Materials Science and Engineering, University of North Texas
Bibliographic description (Ukraine): Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma / Maykel Gonzalez Torres, Carolina Munoz Torres, Ataulfo Martinez Torres, Susana Vargas Munoz, Rogelio Rodriguez Talavera, Alvaro de Jesus Ruiz-Baltazar, Witold Brostow // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2017. — Vol 11. — No 4. — P. 437–444.
Bibliographic description (International): Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma / Maykel Gonzalez Torres, Carolina Munoz Torres, Ataulfo Martinez Torres, Susana Vargas Munoz, Rogelio Rodriguez Talavera, Alvaro de Jesus Ruiz-Baltazar, Witold Brostow // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2017. — Vol 11. — No 4. — P. 437–444.
Is part of: Chemistry & Chemical Technology, 4 (11), 2017
Issue: 4
Volume: 11
Issue Date: 20-Jan-2017
Publisher: Lviv Politechnic Publishing House
Place of the edition/event: Lviv
Keywords: цисплатин
індуційно-зв‘язана плазма
препарат від раку
cisplatin
inductively-coupled plasma
cancer drug
Number of pages: 8
Page range: 437-444
Start page: 437
End page: 444
Abstract: Розглянуто можливість кількісного визна- чення цис-діаміндихлороплатини(II), відомої як цисплатин, безпосереднім застосуванням індуктивно зв’язаної плазми, зокрема визначенням концентрації платини з цисплатину у воді. Доведено, що загальна концентрація препарату може бути кількісно визначена через вміст платини з прийнятною лінійністю, чіткістю, повторюваністю, точністю, межею виявлення та межею кількісного визначення. Показана можливість застосування методу для моніторингу якості контрольних зразків для нормативного подання цисплатину та для визначення профілів вивільнення цисплатину в біомаркерних імплантатах in vitro.
Cis-diaminedichloroplatinum(II), also known as cisplatin, has been quantified by use of inductivelycoupled plasma. We measured cisplatin indirectly by determining the platinum concentration in the samples. We focus on the determination of Pt from cisplatin in water. We demonstrate that the total concentration of the drug can be quantified through the content of platinum with acceptable linearity, precision, repeatability, accuracy, limit of detection and limit of quantification. Our method is applicable among others for monitoring quality of control samples for cisplatin regulatory submissions and for determination of the cisplatin release profiles in biomarker implants in vitro.
URI: https://ena.lpnu.ua/handle/ntb/42125
Copyright owner: © Національний університет „Львівська політехніка“, 2017
© Torres M., Torres C., Torres A., Muñoz S., Talavera R., Ruíz-Baltazar A., Brostow W., 2017
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[3] Dasari S., Tchounwou P., Eur. J. Pharmacol., 2014, 740, 364.https://doi.org/10.1016/j.ejphar.2014.07.025
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[47] Owens G., Singh R., Foroutan F. et al., Prog. Mat. Sci., 2016,77, 1. https://doi.org/10.1016/j.pmatsci.2015.12.001
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