https://oldena.lpnu.ua/handle/ntb/42125
Title: | Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma |
Other Titles: | Оцінка методу квантифікації платини у цисплатині індуційно-зв’язаною плазмою |
Authors: | Torres, Maykel Gonzalez Torres, Carolina Munoz Torres, Ataulfo Martinez Munoz, Susana Vargas Talavera, Rogelio Rodriguez Ruiz-Baltazar, Alvaro de Jesus Brostow, Witold |
Affiliation: | Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México Centro de Geociencias, Universidad Nacional Autónoma de México, Campus Juriquilla Laboratorio de Neurobiologia Molecular y Celular, Instituto de Neurobiología (INB), Universidad Nacional Autónoma de México Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México Department of Materials Science and Engineering, University of North Texas |
Bibliographic description (Ukraine): | Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma / Maykel Gonzalez Torres, Carolina Munoz Torres, Ataulfo Martinez Torres, Susana Vargas Munoz, Rogelio Rodriguez Talavera, Alvaro de Jesus Ruiz-Baltazar, Witold Brostow // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2017. — Vol 11. — No 4. — P. 437–444. |
Bibliographic description (International): | Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma / Maykel Gonzalez Torres, Carolina Munoz Torres, Ataulfo Martinez Torres, Susana Vargas Munoz, Rogelio Rodriguez Talavera, Alvaro de Jesus Ruiz-Baltazar, Witold Brostow // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2017. — Vol 11. — No 4. — P. 437–444. |
Is part of: | Chemistry & Chemical Technology, 4 (11), 2017 |
Issue: | 4 |
Volume: | 11 |
Issue Date: | 20-Jan-2017 |
Publisher: | Lviv Politechnic Publishing House |
Place of the edition/event: | Lviv |
Keywords: | цисплатин індуційно-зв‘язана плазма препарат від раку cisplatin inductively-coupled plasma cancer drug |
Number of pages: | 8 |
Page range: | 437-444 |
Start page: | 437 |
End page: | 444 |
Abstract: | Розглянуто можливість кількісного визна-
чення цис-діаміндихлороплатини(II), відомої як цисплатин,
безпосереднім застосуванням індуктивно зв’язаної плазми,
зокрема визначенням концентрації платини з цисплатину у
воді. Доведено, що загальна концентрація препарату може
бути кількісно визначена через вміст платини з прийнятною
лінійністю, чіткістю, повторюваністю, точністю, межею
виявлення та межею кількісного визначення. Показана
можливість застосування методу для моніторингу якості
контрольних зразків для нормативного подання цисплатину та
для визначення профілів вивільнення цисплатину в біомаркерних
імплантатах in vitro. Cis-diaminedichloroplatinum(II), also known as cisplatin, has been quantified by use of inductivelycoupled plasma. We measured cisplatin indirectly by determining the platinum concentration in the samples. We focus on the determination of Pt from cisplatin in water. We demonstrate that the total concentration of the drug can be quantified through the content of platinum with acceptable linearity, precision, repeatability, accuracy, limit of detection and limit of quantification. Our method is applicable among others for monitoring quality of control samples for cisplatin regulatory submissions and for determination of the cisplatin release profiles in biomarker implants in vitro. |
URI: | https://ena.lpnu.ua/handle/ntb/42125 |
Copyright owner: | © Національний університет „Львівська політехніка“, 2017 © Torres M., Torres C., Torres A., Muñoz S., Talavera R., Ruíz-Baltazar A., Brostow W., 2017 |
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Appears in Collections: | Chemistry & Chemical Technology. – 2017. – Vol. 11, No. 4 |
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