https://oldena.lpnu.ua/handle/ntb/40467| Title: | New heterocyclic scaffolds with thiophene and 1,2,4-triazole rings |
| Authors: | Tupychak, Mykola Shyyka, Olga Pokhodylo, Nazariy Obushak, Mykola |
| Affiliation: | Ivan Franko National University of Lviv |
| Bibliographic description (Ukraine): | New heterocyclic scaffolds with thiophene and 1,2,4-triazole rings / Mykola Tupychak, Olga Shyyka, Nazariy Pokhodylo, Mykola Obushak // Litteris et Artibus : proceedings, 23–25 November, 2017. — Lviv : Lviv Polytechnic Publishing House, 2017. — P. 56–57. — (6th International academic conference «Chemistry & chemical technology 2017» (CCT-2017)). |
| Bibliographic description (International): | New heterocyclic scaffolds with thiophene and 1,2,4-triazole rings / Mykola Tupychak, Olga Shyyka, Nazariy Pokhodylo, Mykola Obushak // Litteris et Artibus : proceedings, 23–25 November, 2017. — Lviv : Lviv Polytechnic Publishing House, 2017. — P. 56–57. — (6th International academic conference «Chemistry & chemical technology 2017» (CCT-2017)). |
| Is part of: | Litteris et Artibus : матеріали, 2017 Litteris et Artibus : proceedings, 2017 |
| Conference/Event: | 7th International youth science forum «Litteris et Artibus» |
| Journal/Collection: | Litteris et Artibus : матеріали |
| Issue Date: | 23-Dec-2017 |
| Publisher: | Видавництво Львівської політехніки Lviv Polytechnic Publishing House |
| Place of the edition/event: | Львів Lviv |
| Temporal Coverage: | 23–25 листопада 2017 року 23–25 November, 2017 |
| Keywords: | 2-aminothiophene 3-aminothiophene 1 2 4- triazoles aminohydrazones thienotriazolopyrimidines triazolothiadiazines |
| Number of pages: | 2 |
| Page range: | 56-57 |
| Start page: | 56 |
| End page: | 57 |
| Abstract: | Some chemical modifications of the Gewald 2- amino-thiophenes and 3-aminothiophenes were established. A number of new substituted thienotriazolopyrimidines, thienotriazoles and thiophenyl-triazolothiadiazine were obtained. This study provides new approaches to the construction of substituted 1H-1,2,4-triazoles bearing thiophene core and allows to use data in medical chemistry for further drug discover. |
| URI: | https://ena.lpnu.ua/handle/ntb/40467 |
| ISBN: | 978-966-941-108-2 |
| Copyright owner: | © Національний університет “Львівська політехніка”, 2017 |
| References (Ukraine): | [1]. R.M. Mohareb, A.E.M. Abdallah, M.H.E. Helal, S.M.H. Shaloof, “Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents”, Acta Pharm., vol.66, pp. 53–68, 2016. [2]. N.B. Saidov, V.A Georgiyants, E.Yu. Lipakova, “Synthesis and pharmacological potential of new 3- mercapto-4-amino(pyrrolyl-1)-5-(thienyl-2)-1,2,4- triazole(4H) derivatives”, Pharm. Chem. J., vol. 51,no. 1, pp. 26−29, 2017. [3]. S. Botros, O.M. Khalil, M.M Kamel, Ya.S. El-Dash, “Synthesis, Characterization and Cytotoxicity of Substituted [1]Benzothieno[3,2-e][1,2,4]triazolo[4,3- a]pyrimidines”, Acta Chim. Slov., vol. 64, pp. 102–116, 2017. [4]. H.N. Hafez, S.A. Alsalaman, A-R.B.A. El-Gazzar, «Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents” Acta Pharm., vol.67, pp. 275–292, 2017. [5]. B. Zhang,, Y.-H. Li, Y. Liu, Y.-R. Chen, E.-S. Pan, W.-W. You, P.-L. Zhao, “Design, synthesis and biological evaluation of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines bearing furan and thiophene nucleus” Eur. J. Med. Chem., vol. 103, pp. 335−350, 2015. [6]. N.D. Obushak, N.T. Pokhodylo, I.I. Krupa, V.S. Matiichuk, “Synthesis of Substituted 4-([1,2,4] Triazolo[3,4-b]-[1,3,4]thiadiazol-6-yl)-quinolines”, Russ. Journ. of Org. Chem., vol. 43, no. 8,pp. 1223−1227, 2007. [7]. N.T. Pokhodylo, V. S. Matiychuk., M.D. Obushak, “New convenient synthesis of 2,3- diaminothieno[2,3-d]pyrimidin-4(3H)-one derivates from substituted alkyl 2-(1H-tetrazol-1-yl)thiophene-3-carboxylates”, Tetrahedron, vol. 64, no. 7, pp. 1430−1434, 2008. |
| References (International): | [1]. R.M. Mohareb, A.E.M. Abdallah, M.H.E. Helal, S.M.H. Shaloof, "Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents", Acta Pharm., vol.66, pp. 53–68, 2016. [2]. N.B. Saidov, V.A Georgiyants, E.Yu. Lipakova, "Synthesis and pharmacological potential of new 3- mercapto-4-amino(pyrrolyl-1)-5-(thienyl-2)-1,2,4- triazole(4H) derivatives", Pharm. Chem. J., vol. 51,no. 1, pp. 26−29, 2017. [3]. S. Botros, O.M. Khalil, M.M Kamel, Ya.S. El-Dash, "Synthesis, Characterization and Cytotoxicity of Substituted [1]Benzothieno[3,2-e][1,2,4]triazolo[4,3- a]pyrimidines", Acta Chim. Slov., vol. 64, pp. 102–116, 2017. [4]. H.N. Hafez, S.A. Alsalaman, A-R.B.A. El-Gazzar, "Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents" Acta Pharm., vol.67, pp. 275–292, 2017. [5]. B. Zhang,, Y.-H. Li, Y. Liu, Y.-R. Chen, E.-S. Pan, W.-W. You, P.-L. Zhao, "Design, synthesis and biological evaluation of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines bearing furan and thiophene nucleus" Eur. J. Med. Chem., vol. 103, pp. 335−350, 2015. [6]. N.D. Obushak, N.T. Pokhodylo, I.I. Krupa, V.S. Matiichuk, "Synthesis of Substituted 4-([1,2,4] Triazolo[3,4-b]-[1,3,4]thiadiazol-6-yl)-quinolines", Russ. Journ. of Org. Chem., vol. 43, no. 8,pp. 1223−1227, 2007. [7]. N.T. Pokhodylo, V. S. Matiychuk., M.D. Obushak, "New convenient synthesis of 2,3- diaminothieno[2,3-d]pyrimidin-4(3H)-one derivates from substituted alkyl 2-(1H-tetrazol-1-yl)thiophene-3-carboxylates", Tetrahedron, vol. 64, no. 7, pp. 1430−1434, 2008. |
| Content type: | Conference Abstract |
| Appears in Collections: | Litteris et Artibus. – 2017 р. |
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2017_Tupychak_M-New_heterocyclic_scaffolds_56-57.pdf | 153.72 kB | Adobe PDF | View/Open | |
| 2017_Tupychak_M-New_heterocyclic_scaffolds_56-57__COVER.png | 509.24 kB | image/png | View/Open |
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