Synthesis, structure and properties of naphthoquinone derivatives, containing amino acid and heterocyclic moieties

Abstract

The quinone moiety is an important part of many biologically active natural products and their synthetic analogues [1,2]. Natural and synthetic quinones exhibit a variety of biological activities such as cytotoxic, antiviral, anti-inflammatory, antimalarial, antibacterial, antifungal and antiproliferative [3-7] properties. Various 2,3-disubstituted 1,4-naphthoquinone derivatives can be prepared from 2,3-dichloro-1,4-naphthoquinone by its reactions with amino- andhydroxy substituted compounds.